The university is in the process of established Regional/Study Centres in the district of Punjab: Amritsar, Barnala, Bathinda, Faridkot, Fatehgarh Sahib, Fazilka, Ferozepur, Gurdaspur, Hoshiarpur, Jalandhar, Kapurthala, Ludhiana, Mansa, Moga, Muktsar, Shahid Bhagat Singh Nagar, Pathankot, Patiala, Rupnagar, Sahibzada Ajit Singh Nagar (Mohali) Sangrur, Tarn Taran.
Regional Centres are responsible for promotion of the ODL system in the each district. Regional Centres are also responsible for the delivery of programmes and student support services and organization of staff development programmes
The major activities of a Regional Centre can be broadly categorized as academic, administrative and promotional. The Regional Centres are responsible for the promotion of the Open University system; development, maintenance and monitoring of Study Centres and Student Support Services; and organisation of staff development programmes in the region, for training coordinators/counsellors/other functionaries.
Regional Centres, is the sub-office of the University for all practical purposes, and also intended to act as resource centre of the University in respective regions